In what looks to be a lopsided contest, the winless Detroit Lions go up against the AFC-best record Tennessee Titans on Thanksgiving Day in Detroit.

Coming off their first loss of the season Sunday (34-13 vs the Jets), the Titans can be counted on to come out strong to get back on track.  On the other hand,  the Lions are hoping against hope that they can put an end to the string of losses they’ve suffered this season.

Detroit Coach Rod Marinelli is taking the blame on himself, but let’s face it, he’s not the one on the field.  The Lions need to dig deep to stay with the Titans, who they have an all-time record of 3-6 against, including a close loss (24-21) on their only other Thanksgiving meeting in 1992.

Look for a blowout here.  I wouldn’t expect the Lions to get more than 10 points.

The Denver Broncos invade Cleveland to take on the Browns. The last meeting between the two was back in 2006 that resulted in a 17-7 win for the Denver Broncos.

Tonight, the Cleveland fan favorite, quarterback Brady Quinn, out of Notre Dame, will get his first career start. He is replacing starter Derek Johnson, who made the Pro Bowl in 2007 but has been lead the Browns to a disappointing 3-5 start.

In head to head competition, the Broncos own the Browns, winning 7 in a row. They lead the series 19-5, that includes playoffs meetings.

Last week the Cleveland Browns lost at home to the Ravens, giving up 17 unanswered points in the 4th quarter. Denver also lost last week, 26-17 at home to the Miami Dolphins. But the Broncos are still in a first place tie with the Indianapolis in the AFC South.

You can bet the “Dog Pound” will be abuzz tonight, as Brady Quinn gets his first start. The Browns (3-5) are in the 3rd place in their conference behind the Pittsburgh Steelers and the Baltimore Ravens. They have four top-10 teams the rest of the way. If they lose tonight, it’s sayonara for the Browns.